Sometimes, something 180 degrees away is what works best.  You can’t do it all the time, but it’s one of the first things that I consider.  Here are three examples.

1. The opposite of what anyone would think: Homer Simpson, “If Jesus had a gun, he’d be alive today.” (I thought I’d fall off the couch when I heard that.)
2. Wally, on Contemporary Christian Music network WAY-FM: instead of automatically playing an artist’s songs when he’d have that artist on as a guest, he’d do “Win it to Spin it,” meaning that the artist had to do some challenge in less time than Wally did it in order to get his/her song played.  One I remember was when he had a singer form a pyramid of Spam “cakes” – without using his HANDS!  (The guy had to stack them up into a pyramid with his MOUTH.  Ewww!  Hilarious on the air, and as a YouTube video.)
3. Once when I was on the air, my boss wanted me to do an all-request hour every Friday night.  After doing it the “plain vanilla” way a couple of times, I went in exactly the opposite direction, saying “This is an all-request hour, but I’M doing all the requesting.”  Totally unexpected, I had more people call in when they COULDN’T make a request than when they could.  (A couple of weeks later, when I got a novelty album with 20 different versions of the song “Louie Louie,” I started the hour with “You can request any song you want… as long as it’s ‘Louie Louie.'”  Believe me, there’s nothing funnier than hearing an “anthem” song done in Mariachi band style, or as a waltz… or hearing the same song requested for an entire hour.)

Try the Opposite once in a while.  It opens up brand new roads.